![]() The drug should not be withdrawn from the therapeutic regimen while there remains the possibility of infection except if a significant adverse reaction occurs. Treatment with SILVADENE Cream 1% should be continued until satisfactory healing has occurred, or until the burn site is ready for grafting. However, if individual patient requirements make dressings necessary, they may be used. Administration may be accomplished in minimal time because dressings are not required. Whenever necessary, the cream should be reapplied to any areas from which it has been removed by patient activity. The cream should be applied once to twice daily to a thickness of approximately 1/16 inch. The burn areas should be covered with SILVADENE Cream 1% at all times. The burn wounds are then cleansed and debrided, and SILVADENE Cream 1% (silver sulfadiazine) is applied under sterile conditions. Very rare (less than 0.Prompt institution of appropriate regimens for care of the burned patient is of prime importance and includes the control of shock and pain. Hematologicįrequency not reported: Neutrophil count decreased, white blood cell depression, agranulocytosis, aplastic anemia, thrombocytopenia, hemolytic anemia DermatologicĬommon (1% to 10%): Pruritus, application site rash, eczema, contact dermatitisįrequency not reported: Skin necrosis, erythema multiforme, skin discoloration, burning sensation, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis Renal for Healthcare professionals: SILVADENE U.S. GeneralĪbsorption varies depending upon the percent of body surface area being treated and extent of tissue damage it is possible any adverse reaction associated with sulfonamides may occur. SILVADENE® (silver sulfadiazine) This product information is intended only for residents of the United States. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.Ĭheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Incidence not knownĪpplies to silver sulfadiazine topical: compounding powder, topical cream. These side effects may go away during treatment as your body adjusts to the medicine. Some side effects of silver sulfadiazine topical may occur that usually do not need medical attention. sores, ulcers, or white spots in the mouth or on the lips.Although SSD remains the gold standard in topical burn. Silver sulfadiazine (SSD) was initially formulated as an ointment, but was later incorporated into a hydrophilic cream. red skin lesions, often with a purple center This formulation, known as silver sulfadiazine (Flammazine R Silvadene R), benefits from the inhibitory effect of silver and the antibacterial action of sulphadiazine. ![]()
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